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A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male wing dimorphism.

Authors
  • Li, Binshuang1
  • Bickel, Ryan D1
  • Parker, Benjamin J1
  • Saleh Ziabari, Omid1
  • Liu, Fangzhou1
  • Vellichirammal, Neetha Nanoth2
  • Simon, Jean-Christophe3
  • Stern, David L4
  • Brisson, Jennifer A1
  • 1 Department of Biology, University of Rochester, Rochester, United States. , (United States)
  • 2 University of Nebraska Medical Center, Omaha, United States. , (United States)
  • 3 INRAE, UMR 1349 IGEPP, Le Rheu, France. , (France)
  • 4 Janelia Research Campus of the Howard Hughes Medical Institute, Ashburn, United States. , (United States)
Type
Published Article
Journal
eLife
Publisher
"eLife Sciences Organisation, Ltd."
Publication Date
Mar 06, 2020
Volume
9
Identifiers
DOI: 10.7554/eLife.50608
PMID: 32141813
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Wing dimorphisms have long served as models for examining the ecological and evolutionary tradeoffs associated with alternative phenotypes. Here, we investigated the genetic cause of the pea aphid (Acyrthosiphon pisum) male wing dimorphism, wherein males exhibit one of two morphologies that differ in correlated traits that include the presence or absence of wings. We mapped this trait difference to a single genomic region and, using third generation, long-read sequencing, we identified a 120 kb insertion in the wingless allele. This insertion includes a duplicated follistatin gene, which is a strong candidate gene in the minimal mapped interval to cause the dimorphism. We found that both alleles were present prior to pea aphid biotype lineage diversification, we estimated that the insertion occurred millions of years ago, and we propose that both alleles have been maintained in the species, likely due to balancing selection. © 2020, Li et al.

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