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Large animal models of human cauda equina injury and repair: evaluation of a novel goat model.

Authors
  • Chen, Wen-Tao
  • Zhang, Pei-Xun
  • Xue, Feng
  • Yin, Xiao-Feng
  • Qi, Cao-Yuan
  • Ma, Jun
  • Chen, Bo
  • Yu, You-Lai
  • Deng, Jiu-Xu
  • Jiang, Bao-Guo
Type
Published Article
Journal
Neural Regeneration Research
Publisher
Medknow Publications
Publication Date
Jan 01, 2015
Volume
10
Issue
1
Pages
60–64
Identifiers
DOI: 10.4103/1673-5374.150707
PMID: 25788921
Source
Medline
Keywords
License
Unknown

Abstract

Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysiological examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establishment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.

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