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Laparoscopic splenectomy for immune thrombocytopenia (ITP): long-term outcomes of a modern cohort

Authors
  • Tastaldi, Luciano1
  • Krpata, David M.1
  • Prabhu, Ajita S.1
  • Petro, Clayton C.1
  • Haskins, Ivy N.1
  • Perez, Arielle J.1
  • Alkhatib, Hemasat1
  • Colturato, Iago2
  • Tu, Chao3
  • Lichtin, Alan4
  • Rosen, Michael J.1
  • Rosenblatt, Steven1
  • 1 The Cleveland Clinic Foundation, Comprehensive Hernia Center, Digestive Disease and Surgery Institute, 9500 Euclid Avenue, A-100, Cleveland, OH, 44195, USA , Cleveland (United States)
  • 2 Hospital Amaral Carvalho, Department of Hematology and Medical Oncology, Jau, Brazil , Jau (Brazil)
  • 3 The Cleveland Clinic Foundation, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, USA , Cleveland (United States)
  • 4 The Cleveland Clinic Foundation, Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland, OH, USA , Cleveland (United States)
Type
Published Article
Journal
Surgical Endoscopy
Publisher
Springer-Verlag
Publication Date
Jul 09, 2018
Volume
33
Issue
2
Pages
475–485
Identifiers
DOI: 10.1007/s00464-018-6321-y
Source
Springer Nature
Keywords
License
Yellow

Abstract

BackgroundThe advent of newer second-line medical therapies (SLMT) for immune thrombocytopenia (ITP) has contributed to decreased rates of splenectomy, following a trend to avoid or delay surgery. We aimed to characterize the long-term outcomes of laparoscopic splenectomy (LS) for ITP at our institution, examining differences in LS efficiency when performed before or after SLMTs.MethodsAdults with primary ITP who underwent LS between 2002 and 2016 were identified. Retrospective review of electronic medical records was supplemented with telephone interviews. Treatment response was defined according to current guidelines as complete responders (CR), responders (R), and non-responders (NR). Kaplan–Meier estimates assessed relapse-free rates, and predictors of long-term response were investigated using logistic regression.Results109 patients met inclusion criteria, from which 42% were treated with an SLMT before referral to LS. LS was completed in all cases, with no conversions or intraoperative complications. The perioperative morbidity was 7.3%, including 3 deep vein and 2 portal vein thrombosis, one reoperation for bleeding, and no mortalities. Splenectomy was initially effective in 99 patients (CR + R = 90.8%), and 10 patients were NR. At a median 62-month follow-up, 25 patients relapsed, resulting in a 68% CR + R rate. Proportion of CR + R was similar in patients who previously received SLMT and those who did not (61 vs. 76.7%, p = 0.08). CR + R patients were younger (45 vs. 53, p = 0.03), had higher preoperative platelet counts (36 vs. 19, p = 0.01), and experienced a higher increment in platelet counts during hospital stay (117 vs. 38, p < 0.001) as well as 30-days postoperatively (329 vs. 124, p < 0.001). Only a robust response in platelet count at 30-days postoperatively was independently associated with long-term response (OR 1.005, p = 0.006).ConclusionLS was curative in 68% of patients, with no statistically significant difference when performed before or after SLMTs. Outcomes remain challenging to predict preoperatively, with only a robust increase in platelet counts on short term being associated with long-term response.

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