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Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats.

Authors
  • Nishi, Toshio1
  • Yamamoto, Yuta1
  • Yamagishi, Naoko1
  • Iguchi, Mikitaka2
  • Tamai, Hideyuki2
  • Ito, Takao1
  • Tsuruo, Yoshihiro1, 3
  • Ichinose, Masao2
  • Kitano, Masayuki2
  • Ueyama, Takashi1
  • 1 Department of Anatomy and Cell Biology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan. , (Japan)
  • 2 2nd Department of Internal Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan. , (Japan)
  • 3 Department of Anatomy and Cell Biology, Tokushima University Graduate School of Medical Science, Tokushima, Japan. , (Japan)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Mar 01, 2018
Volume
70
Issue
3
Pages
383–392
Identifiers
DOI: 10.1111/jphp.12870
PMID: 29355950
Source
Medline
Keywords
License
Unknown

Abstract

Lansoprazole inhibits hepatic fibrogenesis, at least during the early stages, in CDAA diet-induced NASH model rats. The mechanisms might be associated with cytokine suppression but not the inhibition of reactive oxygen species.

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