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Langmuir monolayer study of phospholipid DPPC on the titanium dioxide–chitosan–hyaluronic acid subphases

Authors
  • Ładniak, Agata1
  • Jurak, Małgorzata1
  • Wiącek, Agnieszka Ewa1
  • 1 Maria Curie-Skłodowska University, Department of Interfacial Phenomena, Faculty of Chemistry, Lublin, 20-031, Poland , Lublin (Poland)
Type
Published Article
Journal
Adsorption
Publisher
Springer US
Publication Date
Feb 19, 2019
Volume
25
Issue
3
Pages
469–476
Identifiers
DOI: 10.1007/s10450-019-00037-1
Source
Springer Nature
Keywords
License
Green

Abstract

The studies of model biological membranes consisted of phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were carried out by means of the Langmuir monolayer technique using subphases containing chitosan (Ch), titanium (IV) oxide (TiO2), hyaluronic acid (HA) or mixture of them. The aim was to determine the effect of individual components of subphase and their respective combinations on behavior of the DPPC membrane. The systems were tested at room temperature (20 °C) and at a natural pH of about 4.8, which was close to the pH of the human skin (4.7–5.6). The surface pressure–area per molecule (π–A) isotherms were obtained. Their analysis showed that all substances studied affected the phospholipid membrane which was revealed in the changes of mean molecular area, compression modulus and pressure of the liquid-expanded/liquid-condensed (LE/LC) phase transition. The results were discussed in terms of the nature and strength of mutual interactions. The more profound effect was found at low surface pressures at which the monolayers occurred in more expanded state. However, at the surface pressure corresponding to that of biological membranes, systems had very similar parameters compared to model DPPC isotherm.

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