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Langerhans Cell Histiocytosis with Isolated Cutaneous Involvement Refractory to Polychemotherapy: A Case Report.

Authors
  • Lira-Valero, Francisco Javier1
  • Pulido-Díaz, Nancy1
  • Quintal-Ramírez, Marissa De Jesús1
  • 1 All authors are with the Department of Dermatology at the Instituto Mexicano del Seguro Social and Centro Médico Nacional La Raza in México City, México.
Type
Published Article
Journal
Journal of Clinical and Aesthetic Dermatology
Publication Date
Jan 01, 2020
Volume
13
Issue
1
Pages
32–34
Identifiers
PMID: 32082469
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

BACKGROUND: Langerhans cell histiocytosis (LCH) is a neoplasm of the monocyte-macrophage lineage, characterized by clonal proliferation and dissemination of cells that express CD1a+ and CD207. It is a disorder that predominates in childhood. Although the skin is the second most frequently affected organ (30-60%), isolated cutaneous involvement is rare; its frequency does not exceed 4 to 12 percent of cases. Single system-LCH usually has a good prognosis. We describe a case of LCH with isolated cutaneous involvement that presented in an adult patient and was refractory to polychemotherapy. Copyright © 2020. Matrix Medical Communications. All rights reserved.

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