Changes in land use and sustainability evaluation of wetland in Jiaogang Lake from 1995 to 2013 were analyzed, based on the land use change models and an index system, supported by RS, GIS, and social statistical data. The results showed: (1) dry land, paddy field, and building land were the predominant landscape in the study area. The arable land was mainly converted during 1995-2000, which was driven by the extension of agriculture, and the building land increased significantly during 2010-2013, which was driven by the tourism development. (2) Compared to the beginning research area, the building land increased by 123.3%, and the wetland decreased by 23.15%. The land system was at risk for a low proportion of wetland, scarcity of unused land, and the fragmented landscape. (3) The regional sustainability results were bad level, bad level, poor level, good level, and poor level during the different periods, with some room for improvement. (4) The fitness of regional sustainability in study area yielded satisfactory results in 2010, owing to the rapid growth of regional productivity and the regional stability. Since 2010, with the increasing environmental load, the regional sustainability fell down to the poor level. The obstruction of sustainable development is necessary to be addressed in the study area.