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Effects of Whole-Grain and Sugar Content in Infant Cereals on Gut Microbiota at Weaning: A Randomized Trial.

Authors
  • Plaza-Diaz, Julio1, 2, 3
  • Bernal, Maria Jose4, 5
  • Schutte, Sophie4, 5
  • Chenoll, Empar6
  • Genovés, Salvador6
  • Codoñer, Francisco M6
  • Gil, Angel1, 2, 7, 8
  • Sanchez-Siles, Luis Manuel4, 5
  • 1 Department of Biochemistry & Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain. , (Spain)
  • 2 Instituto de Investigación Biosanitaria IBS. GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain. , (Spain)
  • 3 Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. , (Canada)
  • 4 Research and Nutrition Department, Hero Group, 30820 Alcantarilla, Murcia, Spain. , (Spain)
  • 5 Institute for Research and Nutrition, Hero Group, 5600 Lenzburg, Switzerland. , (Switzerland)
  • 6 Biopolis-ADM, 46980 Paterna, Spain. , (Spain)
  • 7 Biomedical Research Center, Institute of Nutrition & Food Technology "José Mataix", University of Granada, 18071 Granada, Spain. , (Spain)
  • 8 CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain. , (Spain)
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Apr 28, 2021
Volume
13
Issue
5
Identifiers
DOI: 10.3390/nu13051496
PMID: 33925049
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The introduction of complementary foods during infancy marks an important step in the development of the infant gut microbiome. Infant cereals are popular weaning foods but consistent evidence on their effect on the intestinal microbiota, especially when differing in nutritional quality, is lacking. Fecal samples from 4-7-month-old Spanish infants who consumed infant cereals differing in whole grain and sugar content as first weaning foods were analyzed on changes in microbial composition by massively parallel sequencing of the 16S ribosomal RNA gene at baseline and after 7 weeks of intervention. Samples were obtained from a previous trial conducted in Spain demonstrating whole-grain cereal acceptability. In total, samples of 18 infants consuming 0% whole grain cereals with 24 g sugar (0-WG) and 25 infants consuming 50% whole grain cereals with 12 g sugar (50-WG) were analyzed. Microbial composition changed significantly over time (p = 0.001), per intervention group (p = 0.029) and per infant (p = 0.001). Abundance of genus Veillonella increased in both groups while Enterococcus decreased. Within the 0-WG group, phylum Actinobacteria decreased along with genus Bifidobacterium. In the 50-WG, we observed an increase in Lachnoclostridium and Bacteroides. In addition, 50-WG decreased Proteobacteria and Escherichia to levels lower than 0-WG. Although weaning itself appeared to be responsible for most changes, the increased presence of anaerobic fermenters together with inhibition of pathogenic Escherichia may indicate a supporting effect of infant cereals with 50% whole grains and a reduced sugar content over infant cereals manufactured with refined hydrolyzed flours on the infant microbiota. In fact, using a novel methodology for the identification of microbial signatures, we found two groups of microbial taxa predictive of infants consuming enriched whole-grain infant cereals with a high predictive value of about 93%.

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