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Lactate dehydrogenase isozyme patterns of human platelets and bovine lens fibers.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
150
Issue
3704
Pages
1735–1737
Identifiers
PMID: 5858028
Source
Medline

Abstract

Human platelets and bovine lens fibers contain lactate dehydrogenase-3 (LDH-3) as the predominant isozyme but only very faint traces of LDH-5. Since the platelets and lens fibers, like mature human erythrocytes, lack a nucleus, the results strengthen the case for a previously developed association between LDH-5 and the cell nucleus. These three cell types are mainly anaerobic, and therefore their isozyme patterns are incompatible with the theory that anaerobic tissues exhibit predominantly LDH-5 and aerobic tissues mainly LDH-1.

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