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Lack of vertical transmission of Hantaan virus from persistently infected dam to progeny in laboratory mice.

Authors
  • Taruishi, Midori
  • Yoshimatsu, Kumiko
  • Hatsuse, Rei
  • Okumura, Megumi
  • Nakamura, Ichiro
  • Arikawa, Jiro
Type
Published Article
Journal
Archives of virology
Publication Date
Jan 01, 2008
Volume
153
Issue
8
Pages
1605–1609
Identifiers
DOI: 10.1007/s00705-008-0156-0
PMID: 18612586
Source
Medline
License
Unknown

Abstract

It is unclear how the hantaviruses are transferred from infected to uninfected rodents. We studied the status of persistently infected laboratory mice and examined the frequency of viral transmission to their offspring. Expression of Hantaan virus nucleocapsid protein was detected in the lungs of persistently infected dams. None of the progeny displayed viral antigen, although they were strongly positive for IgG antibodies against hantavirus. There was neither hantavirus RNA nor virus-specific IgM antibodies or virus-specific CD8(+) T cells in the progeny. These results did not show any indication for a vertical transmission of hantaviruses, at least in the laboratory mouse model studied.

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