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Lack of response to intravenous sodium thiosulfate in three cases of extensive connective tissue disease-associated calcinosis cutis.

Authors
  • Song, P1
  • Fett, N M2
  • Lin, J3
  • Merola, J F4
  • Costner, M5
  • Vleugels, R A4
  • 1 Department of Dermatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, U.S.A. , (Israel)
  • 2 Department of Dermatology, Oregon Health and Science University, Portland, OR, U.S.A.
  • 3 Department of Medicine, Division of Rheumatology, Stanford University, Stanford, CA, U.S.A.
  • 4 Brigham and Women's Hospital, Department of Dermatology, Harvard Medical School, Boston, MA, U.S.A.
  • 5 Southwestern Medical Center and North Dallas Dermatology Associates, University of Texas, Dallas, TX, U.S.A.
Type
Published Article
Journal
British Journal of Dermatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jun 01, 2018
Volume
178
Issue
6
Pages
1412–1415
Identifiers
DOI: 10.1111/bjd.15783
PMID: 28667747
Source
Medline
Language
English
License
Unknown

Abstract

Dystrophic calcinosis cutis is a debilitating condition of calcium salt deposition in the skin often occurring in association with connective tissue disease (CTD). Available treatments for calcinosis cutis are unsatisfactory, but given the recent use of topical and intralesional sodium thiosulfate (STS) to treat calcifying disorders, we sought to describe the use of intravenous (IV) STS for CTD-associated dystrophic calcinosis cutis. We report three patients with long-standing and extensive CTD-associated calcinosis cutis treated with IV STS after having failed multiple prior therapies. All three patients experienced fatigue and nausea with STS infusions, and none of the patients had notable clinical or symptomatic improvement of calcinosis. It remains to be seen whether the administration of IV STS earlier in the onset of calcinosis might be of benefit given that these patients all had long-standing and refractory CTD-associated calcinosis. Given the small number of patients in this series, further investigation into the use of IV STS in calcinosis cutis is warranted. © 2017 British Association of Dermatologists.

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