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Lack of effect of carbonyl cyanide m-chlorophenylhydrazone on KB-5246 accumulation by Staphylococcus aureus.

Authors
  • Y Kotera
  • Y Inoue
  • M Ohashi
  • K Ito
  • M Inoue
Publication Date
Apr 01, 1992
Source
PMC
Keywords
License
Unknown

Abstract

The accumulation of KB-5246 in a quinolone-susceptible strain of Staphylococcus aureus was about 70 times that of norfloxacin. Carbonyl cyanide m-chlorophenylhydrazone increased the accumulation of norfloxacin about eightfold, but it did not influence that of KB-5246. The low efflux of KB-5246 from S. aureus may contribute to its potent antibacterial activity.

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