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Lack of nephrotoxicity of intravenous dimethylsulfoxide.

Authors
  • Bennett, W M
  • Muther, R S
Type
Published Article
Journal
Clinical toxicology
Publication Date
May 01, 1981
Volume
18
Issue
5
Pages
615–618
Identifiers
PMID: 7023808
Source
Medline
License
Unknown

Abstract

Intravenous dimethylsulfoxide (DMSO) was used to treat seven patients with stable spinal cord injuries. Because of drug-associated hemoglobinemia and hemoglobinuria, the patients were studied for subtle evidence of renal tubular dysfunction by serial measurements of urinary beta-2-microglobulin excretion. No increases in tubular protein excretion or decreases in glomerular filtration rate were observed following short-term infusions of 10-40% DMSO. It is concluded that there is no significant short-term nephrotoxicity from intravenous DMSO.

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