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Lack of interference with immunogenicity of a chimeric alphavirus replicon particle-based influenza vaccine by preexisting antivector immunity.

Authors
  • 1
Type
Published Article
Journal
Clinical and vaccine immunology : CVI
1556-679X
Publication Date
Volume
19
Issue
7
Pages
991–998
Identifiers
DOI: 10.1128/CVI.00031-12
PMID: 22623651
Source
Medline
License
Unknown

Abstract

Antivector immunity has been recognized as a potential caveat of using virus-based vaccines. In the present study, an alphavirus-based replicon particle vaccine platform, which has demonstrated robust immunogenicity in animal models, was tested for effects of antivector immunity on immunogenicity against hemagglutinin of influenza virus as a target antigen and efficacy for protection against lethal challenge with the virus. Chimeric alphavirus-based replicon particles, comprising Venezuelan equine encephalitis virus nonstructural and Sindbis virus structural components, induced efficient protective antibody responses, which were not adversely influenced after multiple immunizations with the same vector expressing various antigens.

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