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Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection.

Authors
  • Lye, David C
  • Lee, Vernon J
  • Sun, Yan
  • Leo, Yee Sin
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
May 01, 2009
Volume
48
Issue
9
Pages
1262–1265
Identifiers
DOI: 10.1086/597773
PMID: 19292665
Source
Medline
License
Unknown

Abstract

Thrombocytopenia in dengue infection raises concerns about bleeding risk. Of 256 patients with dengue infection who developed thrombocytopenia (platelet count, < 20 x 10(3) platelets/microL) without prior bleeding, 188 were given platelet transfusion. Subsequent bleeding, platelet increment, and platelet recovery were similar between patients given transfusion and patients not given transfusion. Prophylactic platelet transfusion was ineffective in preventing bleeding in adult patients with dengue infection.

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