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Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients.

Authors
  • Ito, A
  • Ota, M
  • Katsuyama, Y
  • Inoko, H
  • Ohno, S
  • Mizuki, N
Type
Published Article
Journal
Tissue antigens
Publication Date
Nov 01, 2007
Volume
70
Issue
5
Pages
423–426
Identifiers
PMID: 17854429
Source
Medline
License
Unknown

Abstract

Toll-like receptors (TLRs) play an important role in the induction of defense mechanisms of the innate and adaptive immune responses to microbial pathogens. Genetic polymorphisms within the TLR9 gene have been reported to be associated with a variety of inflammatory and infectious diseases. Behçet's disease (BD) is a chronic inflammatory disease, and the etiology of BD has yet to be fully elucidated. We investigated the potential association of the TLR9 gene with susceptibility to BD by analyzing the frequency of nine single nucleotide polymorphisms (SNPs) in a population of 200 Japanese BD patients and 102 randomized controls. Our results showed that SNPs in the TLR9 gene were not significantly associated with susceptibility to BD.

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