Affordable Access

Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis.

Authors
  • Ozkara, Cigdem
  • Uzan, Mustafa
  • Tanriverdi, Taner
  • Baykara, Onur
  • Ekinci, Burcak
  • Yeni, Naz
  • Kafadar, Ali
  • Buyru, Nur
Type
Published Article
Journal
Seizure
Publisher
Elsevier
Publication Date
Jul 01, 2006
Volume
15
Issue
5
Pages
288–291
Identifiers
PMID: 16546408
Source
Medline
License
Unknown

Abstract

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is one of the most common medically intractable epilepsy syndromes and the pathogenesis of HS remains highly obscure. Recent studies demonstrated controversial results about the relationship between interleukin (IL) gene polymorphism and epilepsy in different ethnic groups. This correlation was investigated in Turkish patients with MTLE-HS. The allele distribution of IL-1alpha and IL-1beta in 47 patients of Turkish ancestry was determined and compared with 99 ethnically matched control subjects. Analysis of genotype frequencies between patients and controls showed no statistically significant difference (p>0.05). Our data suggest that IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry.

Report this publication

Statistics

Seen <100 times