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Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid

Authors
  • Mikolasch, Annett1
  • Hammer, Elke1
  • Witt, Sabine2
  • Lindequist, Ulrike3
  • 1 University Greifswald, Felix-Hausdorff-Straße 8, Greifswald, 17489, Germany , Greifswald (Germany)
  • 2 Biometec, Walther-Rathenau-Str. 49a, Greifswald, 17489, Germany , Greifswald (Germany)
  • 3 Institute of Pharmacy University Greifswald, Friedrich-Ludwig-Jahn-Str. 17, Greifswald, 17487, Germany , Greifswald (Germany)
Type
Published Article
Journal
AMB Express
Publisher
Springer Berlin Heidelberg
Publication Date
Oct 02, 2020
Volume
10
Issue
1
Identifiers
DOI: 10.1186/s13568-020-01117-0
Source
Springer Nature
Keywords
License
Green

Abstract

Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains.

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