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Laboratory screening for the diagnosis of children with primary immunodeficiencies.

Authors
  • Carneiro-Sampaio, M M
  • Grumach, A S
  • Manissadjian, A
Type
Published Article
Journal
Journal of Investigational Allergology and Clinical Immunology
Publisher
"Esmon Publicidad, SA"
Publication Date
Jun 01, 1991
Volume
1
Issue
3
Pages
195–200
Identifiers
PMID: 1669577
Source
Medline
License
Unknown

Abstract

To select simple and low-cost laboratory tests that contribute to the diagnosis of primary immunodeficiencies (PID) in children, the medical records of 98 patients with PID were analyzed. White blood cell counts, serum IgG, IgM and IgA determinations, Shick test, isohemagglutinin titers, delayed cutaneous hypersensitivity tests, nitro blue tetrazolium test and hemolytic complement (CH50) determination associated with clinical data led to the diagnosis in 95% of cases. Applying this laboratory screening to patient series studies in other countries, the diagnosis was suggested in at least 92% of the cases. This screening proposal may be used as a guideline in the standardization of complementary tests for the diagnosis of immunodeficiencies in pediatric centers of developing countries and also at the primary medical care level in developed countries.

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