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Label-free and ultrasensitive fluorescence detection of cocaine based on a strategy that utilizes DNA-templated silver nanoclusters and the nicking endonuclease-assisted signal amplification method.

Authors
  • Zhang, Kai
  • Wang, Ke
  • Zhu, Xue
  • Zhang, Jue
  • Xu, Lan
  • Huang, Biao
  • Xie, Minhao
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Jan 07, 2014
Volume
50
Issue
2
Pages
180–182
Identifiers
DOI: 10.1039/c3cc47418f
PMID: 24217291
Source
Medline
License
Unknown

Abstract

A general and reliable strategy for the detection of cocaine was proposed utilizing DNA-templated silver nanoclusters as signal indicators and the nicking endonuclease-assisted signal amplification method. This strategy can detect cocaine specifically with a detection limit as low as 2 nM by using a small volume of 5 μL.

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