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L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas.

Authors
  • Fogel, Mina
  • Gutwein, Paul
  • Mechtersheimer, Sabine
  • Riedle, Svenja
  • Stoeck, Alexander
  • Smirnov, Asya
  • Edler, Lutz
  • Ben-Arie, Alon
  • Huszar, Monica
  • Altevogt, Peter
Type
Published Article
Journal
The Lancet
Publisher
Elsevier
Publication Date
Sep 13, 2003
Volume
362
Issue
9387
Pages
869–875
Identifiers
PMID: 13678974
Source
Medline
License
Unknown

Abstract

L1 is overexpressed in ovarian and uterine carcinomas and is associated with short survival. L1 can serve as a new marker for prediction of clinical outcome and could be helpful to identify patients with uterine tumours who are at high risk for recurrent disease. L1 expression and cleavage could promote dissemination of tumours by facilitating cell migration.

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