Affordable Access

L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies.

Authors
  • Chiechio, S1
  • Copani, A
  • Nicoletti, F
  • Gereau, R W 4th
  • 1 Washington University Pain Center and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Type
Published Article
Journal
Current Neuropharmacology
Publisher
Bentham Science
Publication Date
Jul 01, 2006
Volume
4
Issue
3
Pages
233–237
Identifiers
PMID: 18615142
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of Lacetylcarnitine as tested in clinical studies and in animal models of nerve injury.

Report this publication

Statistics

Seen <100 times