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[L-2 hydroxyglutaric aciduria in a patient with Klinefelter syndrome].

Authors
  • Pascual-Castroviejo, I
  • Pascual-Pascual, S I
  • Velázquez Fragua, R
  • Ferrer, I
  • Ugarte, M
  • García-Segura, J M
Type
Published Article
Journal
Neurología (Barcelona, Spain)
Publication Date
Mar 01, 2005
Volume
20
Issue
2
Pages
90–93
Identifiers
PMID: 15726477
Source
Medline
License
Unknown

Abstract

We present a of 22 years old patient who has a severe cerebellar disease that started during the first years of life, borderline mental level, epilepsy and Klinefelter syndrome. Brain magnetic resonance (MR) imaging revealed swollen white matter with a loss of signal on T1-weighted slices and an increase in signal intensity on T2-weighted images in both cerebral hemispheres and in both cerebellar dentate nuclei. MRI alterations did not change during the studies performed from 4 to 21 years. Blood and urine were analyzed and showed great elevation of L-2-hydroxyglutaric acid (L-2-HGA) and more discrete elevation of its metabolites and lysine. The parents of the patient are first cousins.

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