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KO(t)Bu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones.

Authors
  • Yadav, Abhimanyu
  • Verma, Ajay
  • Patel, Saket
  • Kumar, Amit
  • Rathore, Vandana
  • Kumar, Shailesh
  • Kumar, Sangit
Type
Published Article
Journal
Chemical Communications
Publisher
The Royal Society of Chemistry
Publication Date
Jul 25, 2015
Volume
51
Issue
58
Pages
11658–11661
Identifiers
DOI: 10.1039/c5cc02964c
PMID: 26100391
Source
Medline
License
Unknown

Abstract

The KO(t)Bu-mediated annulation of acetonitrile with aldehyde was observed, in which the cleavage of four C(sp(3))-H bonds occurred and a total of eight new bonds were formed during the synthesis of substituted dihydropyridinones in the presence of peroxide. Furthermore, dihydropyridinones have been transformed into pyridinones using KO(t)Bu in DMSO.

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