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Knowledge gap about immune checkpoint inhibitors among rheumatologists and medical students: a survey.

Authors
  • da Silva, Guilherme Ferreira Maciel1
  • Landim, Joaquim Ivo Vasques Dantas1
  • Dos Santos Brasil, Lucas Teixeira1
  • Plens, Isabella Cabral Marinho1
  • Silva, Andressa Laura Castro1
  • Scheinberg, Morton Aaron2
  • Rocha, Francisco Airton Castro3, 4
  • 1 Department of Internal Medicine, Liga de Reumatologia e Doenças Autoimunes, Faculdade de Medicina, Universidade Federal Do Ceará, Fortaleza, CE, Brazil. , (Brazil)
  • 2 Real e Benemérita Sociedade de Beneficência Portuguesa, São Paulo, SP, Brazil. , (Brazil)
  • 3 Department of Internal Medicine, Liga de Reumatologia e Doenças Autoimunes, Faculdade de Medicina, Universidade Federal Do Ceará, Fortaleza, CE, Brazil. [email protected] , (Brazil)
  • 4 Instituto de Biomedicina, Laboratório de Investigação em Osteoartropatias, Rua Cel. Nunes de Melo, 1315, 1º. Andar, Rodolfo Teófilo, Fortaleza, CE, 60430-270, Brazil. [email protected] , (Brazil)
Type
Published Article
Journal
Rheumatology International
Publisher
Springer-Verlag
Publication Date
May 01, 2021
Volume
41
Issue
5
Pages
939–942
Identifiers
DOI: 10.1007/s00296-020-04674-6
PMID: 32767082
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Previous studies found that physicians working in developed countries in Europe and in the USA declared insufficient knowledge concerning immune-related adverse events (irAE) following use of immune checkpoint inhibitors (ICI) in cancer treatment. We determined this knowledge gap among rheumatologists and medical students (MS) in Brazil. A web-based structured survey or a direct interview was applied to 1428 board-certified Brazilian rheumatologists and an adapted questionnaire was sent to 840 undergraduate MS attending the last 2 years of Medical Schools in Fortaleza-CE, Brazil, in September 2019. 228 (15.9%) rheumatologists and 145 (17.2%) MS answered the survey; 136 (60%) rheumatologists worked at Institutions with Oncology service. Rheumatologists had 22.6 ± 12.6 years of medical practice, most [116 (50.9%)] worked in private practice and 9 (3.9%) were on training. Fifty-three (23.4%) declared being familiar [40 (17.6%)] or very familiar [13 (5.8%)] with irAE. Almost two-thirds declared having never managed irAE and about a third (38.6%) felt confident in managing such patients. Knowledge among rheumatologists was similar regardless of having more or less than 10 years of practice (P = 0.758). Less than 5% MS declared being familiar with ICI and most have never heard of irAE. There is a large gap concerning knowledge about ICI and irAE among rheumatologists and MS in Brazil. Continuing medical education strategies are needed to improve this knowledge.

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