Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease
- Authors
- Type
- Published Article
- Journal
- Aging Cell
- Publisher
- John Wiley and Sons Inc.
- Publication Date
- Sep 21, 2020
- Volume
- 19
- Issue
- 10
- Identifiers
- DOI: 10.1111/acel.13239
- PMID: 32964663
- PMCID: PMC7576297
- Source
- PubMed Central
- Keywords
- License
- Unknown
- External links
Abstract
Klotho , as an anti‐aging gene, has been studied in the field of AD in recent years. Our data showed that Klotho overexpression inhibited NLRP3 inflammasome activation and promoted Aβ clearance through an increase in M2 type microglia and the regulation of Aβ transporters in APP/PS1 mice, which effectively relieved neuroinflammation and Aβ burden and ameliorated AD‐like phenotypes.
