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Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

Authors
  • Zhao, Yue1
  • Zeng, Chen‐Ye1
  • Li, Xiao‐Hong1
  • Yang, Ting‐Ting1
  • Kuang, Xi1
  • Du, Jun‐Rong1
  • 1 Sichuan University, China , (China)
Type
Published Article
Journal
Aging Cell
Publisher
John Wiley and Sons Inc.
Publication Date
Sep 21, 2020
Volume
19
Issue
10
Identifiers
DOI: 10.1111/acel.13239
PMID: 32964663
PMCID: PMC7576297
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Klotho , as an anti‐aging gene, has been studied in the field of AD in recent years. Our data showed that Klotho overexpression inhibited NLRP3 inflammasome activation and promoted Aβ clearance through an increase in M2 type microglia and the regulation of Aβ transporters in APP/PS1 mice, which effectively relieved neuroinflammation and Aβ burden and ameliorated AD‐like phenotypes.

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