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Kisspeptins and GPR54--the new biology of the mammalian GnRH axis.

Authors
  • Aparicio, Samuel A J R
Type
Published Article
Journal
Cell Metabolism
Publisher
Elsevier
Publication Date
May 01, 2005
Volume
1
Issue
5
Pages
293–296
Identifiers
PMID: 16054076
Source
Medline
License
Unknown

Abstract

Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.

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