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The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis

Authors
  • Cheerambathur, Dhanya K.1, 2
  • Prevo, Bram1, 2
  • Chow, Tiffany-Lynn1, 2
  • Hattersley, Neil1, 2
  • Wang, Shaohe1, 2
  • Zhao, Zhiling1, 2
  • Kim, Taekyung1, 2
  • Gerson-Gurwitz, Adina1, 2
  • Oegema, Karen1, 2
  • Green, Rebecca1, 2
  • Desai, Arshad1, 2
  • 1 Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093, USA
  • 2 Department of Cellular & Molecular Medicine, University of California, San Diego, San Diego, La Jolla, CA 92093, USA
Type
Published Article
Journal
Developmental cell
Publication Date
Mar 25, 2019
Volume
48
Issue
6
Pages
864–872
Identifiers
DOI: 10.1016/j.devcel.2019.02.002
PMID: 30827898
PMCID: PMC6436928
Source
PubMed Central
Keywords
License
Unknown

Abstract

The conserved Knl1/Mis12/Ndc80 (KMN) network constitutes the microtubule-coupling interface at kinetochores in mitosis. Cheerambathur et al. find that the KMN network also acts in the developing sensory nervous system. KMN components concentrate in dendrites of developing neurons and promote their extension, employing the same microtubule-coupling interface that acts in mitosis.

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