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Kinetics of reprogramming in cell fusion hybrids.

Authors
Type
Published Article
Journal
The International journal of developmental biology
Publication Date
Volume
54
Issue
11-12
Pages
1697–1702
Identifiers
DOI: 10.1387/ijdb.103191hc
PMID: 21404190
Source
Medline

Abstract

Somatic cells can obtain pluripotency by fusion with pluripotent stem cells. The resulting fusion hybrids display pluripotential characteristics, such as inactivation of tissue-specific genes, differentiation potential to all three germ layers, and a specific epigenetic state corresponding to the pluripotent cells. However, the fusion hybrid cells are not identical to the pluripotent fusion partner cells although they are similar to the pluripotent cells. Recently, we showed that fusion-induced reprogramming was not a solely unidirectional process. In this review, we address how much somatic cells "remember and lose" their original characteristics after fusion with pluripotent cells.

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