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[The kinetics of lithium in the rat serum, brain and liver].

Authors
  • Lehmann, K
Type
Published Article
Journal
Acta biologica et medica Germanica
Publication Date
Jan 01, 1975
Volume
34
Issue
6
Pages
1043–1047
Identifiers
PMID: 1199620
Source
Medline
License
Unknown

Abstract

The kinetics of lithium in the serum, liver and brain of rats is described. The serum levels resembled those of man, whereas considerable quantitative differences were observed when comparing specific kinetic parameters. The brain level increased with the increasing doses, approaching the corresponding serum level. Concentration differences between different brain areas could be observed only after repeated administrations. Striatum, cortex and hippocampus showed significantly higher levels than the thalamus. The liver content remained low with increasing doses, and was below the brain level.

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