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Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal antibodies, immune bovine serum, and immune bovine colostrum.

Authors
  • Perryman, L E
  • Riggs, M W
  • Mason, P H
  • Fayer, R
Type
Published Article
Journal
Infection and immunity
Publication Date
Jan 01, 1990
Volume
58
Issue
1
Pages
257–259
Identifiers
PMID: 2294054
Source
Medline
License
Unknown

Abstract

Monoclonal antibodies, immune bovine serum, and immune bovine colostral whey neutralized infectivity of Cryptosporidium parvum sporozoites for mice in a time-dependent manner. Immune colostral whey neutralized sporozoites more rapidly and completely than immune serum, monoclonal antibody (MAb) 18.44, or a combination of MAb 18.44 and MAb 17.41. Mice were partially protected against oral challenge with C. parvum oocytes when treated with immune colostral whey, MAb 17.41, or a combination of MAb 17.41 and MAb 18.44.

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