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Kinetics, biodistribution and therapeutic efficacy of hexylester 5-aminolevulinate induced photodynamic therapy in an orthotopic rat bladder tumor model.

Authors
  • El Khatib, S
  • Didelon, J
  • Leroux, A
  • Bezdetnaya, L
  • Notter, D
  • D'Hallewin, M
Type
Published Article
Journal
The Journal of Urology
Publisher
Elsevier
Publication Date
Nov 01, 2004
Volume
172
Issue
5 Pt 1
Pages
2013–2017
Identifiers
PMID: 15540780
Source
Medline
License
Unknown

Abstract

An optimal PDT effect was obtained with 8 mM hALA and a fluence of 20 J/cm2. While different hALA concentrations ind uce identical PpIX fluorescence intensities, the PDT outcome was considerably different. Thus, fluorescence does not necessarily predict the therapeutic efficacy of PDT.

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