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Kinetic model of conduction changes across excitable membranes.

Authors
  • Jain, M K
  • Marks, R H
  • Cordes, E H
Type
Published Article
Journal
Proceedings of the National Academy of Sciences of the United States of America
Publication Date
Oct 01, 1970
Volume
67
Issue
2
Pages
799–806
Identifiers
PMID: 5289023
Source
Medline
License
Unknown

Abstract

A kinetic model describing conduction changes across excitable membranes is proposed. It assumes that a population of discrete membrane sites is distributed among several distinct functional states determined by the voltage across the membrane. Interconversion of these states is postulated to occur by first-order reactions. It provides a satisfactory description of the central aspects of excitable membrane behavior, including current-time and current-voltage relationships, action potential, and effects of inhibitors.

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