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Kinesin and dynein superfamily proteins and the mechanism of organelle transport.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
279
Issue
5350
Pages
519–526
Identifiers
PMID: 9438838
Source
Medline
License
Unknown

Abstract

Cells transport and sort proteins and lipids, after their synthesis, to various destinations at appropriate velocities in membranous organelles and protein complexes. Intracellular transport is thus fundamental to cellular morphogenesis and functioning. Microtubules serve as a rail on which motor proteins, such as kinesin and dynein superfamily proteins, convey their cargoes. This review focuses on the molecular mechanism of organelle transport in cells and describes kinesin and dynein superfamily proteins.

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