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Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplant.

Authors
  • Velardi, Andrea
  • Ruggeri, Loredana
  • Mancusi, Antonella
Type
Published Article
Journal
Current Opinion in Hematology
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jul 01, 2012
Volume
19
Issue
4
Pages
319–323
Identifiers
DOI: 10.1097/MOH.0b013e32835423c3
PMID: 22555394
Source
Medline
License
Unknown

Abstract

Donor-versus-recipient NK-cell alloreactivity is established as a key therapeutic element in human leukocyte antigen haplotype-mismatched haematopoietic transplants in adult acute myeloid leukaemia (AML) and paediatric acute lymphoblastic leukaemia (ALL). NK-cell allotherapy for leukaemia is deployed through stem cell transplantation (and ensuing NK-cell reconstitution) across killer-cell immunoglobulin-like receptor ligand mismatches. Donor-derived NK cells were also reported to respond to cytomegalovirus by acquiring features that are reminiscent of the specificity and memory of adaptive (T-cell) immune responses. As NK cells are the earliest immune cells to recover after transplant, this observation suggests they may contribute to controlling viral reactivation early after transplant.

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