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The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults

Authors
  • lustgarten, michael s.
Publication Date
Dec 30, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Decreased renal function, elevated circulating levels of urea, intestinal levels of urea-degrading bacteria, and gut-derived uremic metabolites are present in end-stage renal disease (ESRD), a cohort that has reduced muscle mass and physical function, and poor muscle composition. This phenotype, defined as the kidney&ndash / gut&ndash / muscle axis, is similarly represented in older adults that do not have ESRD. The purpose of this short communication is to illuminate these findings, and to propose a strategy that can positively impact the kidney&ndash / gut&ndash / muscle axis. For example, dietary fiber is fermented by intestinal bacteria, thereby producing the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate, which affect each component of the kidney&ndash / gut&ndash / muscle axis. Accordingly, a high-fiber diet may be an important approach for improving the kidney&ndash / gut&ndash / muscle axis in ESRD and in older adults that do not have ESRD.

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