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Key role of phosphoinositide 3-kinase class IB in pancreatic cancer.

Authors
  • Edling, Charlotte E
  • Selvaggi, Federico
  • Buus, Richard
  • Maffucci, Tania
  • Di Sebastiano, Pierluigi
  • Friess, Helmut
  • Innocenti, Paolo
  • Kocher, Hemant M
  • Falasca, Marco
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Oct 15, 2010
Volume
16
Issue
20
Pages
4928–4937
Identifiers
DOI: 10.1158/1078-0432.CCR-10-1210
PMID: 20876794
Source
Medline
License
Unknown

Abstract

These data represent the first identification of a tumor-specific accumulation of the PI3K isoform p110γ in human cancer. Further, our results signify a critical role for PI3K/p110γ in pancreatic cancer, and we hypothesize that PI3K/p110γ overexpression is a key event in the disease progression.

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