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Key molecular pathways affected by glaucoma pathology: is predictive diagnosis possible?

Authors
  • Golubnitschaja, Olga1, 2
  • Yeghiazaryan, Kristina1, 2
  • Flammer, Josef2, 3
  • 1 Rheinische Friedrich-Wilhelms-University of Bonn, Department of Radiology, Sigmund-Freud-Str. 25, Bonn, D-53105, Germany , Bonn (Germany)
  • 2 European Association for Predictive, Preventive & Personalised Medicine
  • 3 University of Basel, Department of Ophthalmology, Basel, Switzerland , Basel (Switzerland)
Type
Published Article
Journal
EPMA Journal
Publisher
BioMed Central
Publication Date
Jun 29, 2010
Volume
1
Issue
2
Pages
237–244
Identifiers
DOI: 10.1007/s13167-010-0031-4
Source
Springer Nature
Keywords
License
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Abstract

Prediction and prevention of glaucoma. Neurodegenerative eye disease glaucoma is the second leading cause of blindness with estimated 67 million patients worldwide. Molecular pathomechanisms of glaucoma demonstrate both a considerable overlap with and remarkable particularities compared to other neurodegenerative disorders e.g. Alzheimer’s disease. Identification of pathology-specific biomarker-sets is essential to develop advanced diagnostic approaches and personalised patients’ treatment. Subcellular imaging and expression patterns in blood as the reliable platform for early/predictive glaucoma diagnosis. Following key pathways are affected in glaucoma pathology: stress response, apoptosis and DNA-repair, adhesion, blood-brain-barrier-breakdown, tissue remodelling, transcription regulation, multidrug resistance and energy metabolism.

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