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The Key Events Dose-Response Framework: Its Potential for Application to Foodborne Pathogenic Microorganisms

Authors
  • BUCHANAN, ROBERT L.1
  • HAVELAAR, ARIE H.2
  • SMITH, MARY ALICE3
  • WHITING, RICHARD C.4
  • JULIEN, ELIZABETH5
  • 1 Center for Food Safety and Security Systems, University of Maryland, College Park, MD, USA
  • 2 Centre for Infectious Disease Control Netherlands, National Institute for Public Health and the Environment, Bilthoven, and Division Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
  • 3 Center for Food Safety and the Environmental Health Sciences Department, University of Georgia, Athens, GA, USA
  • 4 Chemical Regulation and Food Safety Center, Exponent, Inc., Bowie, MD, USA
  • 5 International Life Sciences Institute Research Foundation, Washington, DC, USA
Type
Published Article
Journal
Critical Reviews in Food Science and Nutrition
Publisher
Informa UK (Taylor & Francis)
Publication Date
Sep 11, 2009
Volume
49
Issue
8
Pages
718–728
Identifiers
DOI: 10.1080/10408390903116764
PMID: 19690997
PMCID: PMC2840876
Source
PubMed Central
Keywords
License
Green

Abstract

The Key Events Dose-Response Framework (KEDRF) is an analytical approach that facilitates the use of currently available data to gain insight regarding dose-response relationships. The use of the KEDRF also helps identify critical knowledge gaps that once filled, will reduce reliance on assumptions. The present study considers how the KEDRF might be applied to pathogenic microorganisms, using fetal listeriosis resulting from maternal ingestion of food contaminated with L. monocytogenes as an initial example. Major biological events along the pathway between food ingestion and the endpoint of concern are systematically considered with regard to dose (i.e., number of organisms), pathogen factors (e.g., virulence), and protective host mechanisms (e.g., immune response or other homeostatic mechanisms). It is concluded that the KEDRF provides a useful structure for systematically evaluating the complex array of host and pathogen factors that influence the dose-response relationship. In particular, the KEDRF supports efforts to specify and quantify the sources of variability, a prerequisite to strengthening the scientific basis for food safety decision making.

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