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Ketoprofen spray-dried microspheres based on Eudragit RS and RL: study of the manufacturing parameters.

Authors
  • Rassu, Giovanna
  • Gavini, Elisabetta
  • Spada, Gianpiera
  • Giunchedi, Paolo
  • Marceddu, Salvatore
Type
Published Article
Journal
Drug Development and Industrial Pharmacy
Publisher
Informa UK (Taylor & Francis)
Publication Date
Nov 01, 2008
Volume
34
Issue
11
Pages
1178–1187
Identifiers
DOI: 10.1080/03639040801974303
PMID: 18777240
Source
Medline
License
Unknown

Abstract

The preparation of ketoprofen spray-dried microspheres can be affected by the long drug recrystallization time. Polymer type and drug-polymer ratio as well as manufacturing parameters affect the preparation. The purpose of this work was to evaluate the possibility to obtain ketoprofen spray-dried microspheres using the Eudragit RS and RL; the influence of the spray-drying parameters on morphology, dimension, and physical stability of microspheres was studied. Ketoprofen microspheres based on Eudragit blend can be prepared by spray-drying and the nebulization parameters do not influence significantly particle properties; nevertheless, they can be affected by drying and storage methods. No effect of the container material is found.

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