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Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.

Authors
  • 1
  • 1 Department of Pharmaceutical Sciences, College of Pharmacy, Medical University of South Carolina, 280 Calhoun Street, P.O. Box 250140, Charleston, South Carolina 29425, USA.
Type
Published Article
Journal
Journal of the American Chemical Society
Publication Date
Volume
124
Issue
8
Pages
1606–1614
Identifiers
PMID: 11853433
Source
Medline

Abstract

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