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Ketogenic diet: overview, types, and possible anti-seizure mechanisms.

Authors
  • Barzegar, Mohammad1
  • Afghan, Mohammadreza1
  • Tarmahi, Vahid1
  • Behtari, Meysam1
  • Rahimi Khamaneh, Soroor1
  • Raeisi, Sina1
  • 1 Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , (Iran)
Type
Published Article
Journal
Nutritional Neuroscience
Publisher
Maney Publishing
Publication Date
Apr 01, 2021
Volume
24
Issue
4
Pages
307–316
Identifiers
DOI: 10.1080/1028415X.2019.1627769
PMID: 31241011
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The ketogenic diet (KD) has been used for a long time as a therapeutic approach for drug-resistant epilepsy. It is a high-fat, low-carbohydrate, and adequate protein diet. There are various types of KD with some differences in their compositions that mainly include classic KD, medium-chain triglyceride diet, modified Atkins diet, and low glycemic index treatment. The anti-seizure mechanisms of KDs have not yet completely understood but, some possible mechanisms can be theorized. The aim of the present study was to review the various types of KD and explain the probable biochemical mechanisms involved in its anti-seizure property.

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