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Ketamine disrupted storage but not retrieval of information in male rats and apomorphine counteracted its impairing effect.

Authors
  • Pitsikas, Nikolaos1
  • Carli, Mirjana2
  • 1 Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. Electronic address: [email protected] , (Greece)
  • 2 Department of Neurosciences, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. , (Italy)
Type
Published Article
Journal
Neuroscience letters
Publication Date
Oct 15, 2020
Volume
737
Pages
135321–135321
Identifiers
DOI: 10.1016/j.neulet.2020.135321
PMID: 32846219
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Ketamine, a non-competitive NMDA receptor antagonist, has been reported to mimic the cognitive symptoms of schizophrenia in animals. It has been reported to produce learning and memory deficits in rodents. However, there have limited number of reports that investigated the specific components of memory process that are affected with ketamine. In the present study, we investigated the effects of ketamine [8 and 20 mg/kg, intraperitoneally, (i.p.)] on storage and retrieval of information in rats using an object recognition test. We examined also whether a low dose range of the D1/D2 dopamine receptor agonist apomorphine (0.05 and 0.1 mg/kg, i.p.) would counteract the effects of ketamine. The results show that ketamine dose-dependently impaired storage of information while it did not affect rats' retrieval abilities. Administration of apomorphine reversed the ketamine-induced performance deficits in the ORT. The current findings show a differential modulation of post-training memory components (storage and retrieval of information) by ketamine and suggest a functional interaction between dopamine and NMDA receptors in the control of memory storage which may be of relevance to cognitive deficits a core feature of schizophrenia. Copyright © 2020 Elsevier B.V. All rights reserved.

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