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Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma.

Authors
  • Usachov, Valentyn
  • Nahon, Pierre
  • Lunova, Mariia
  • Ziol, Marianne
  • Rufat, Pierre
  • Sutton, Angela
  • Beaugrand, Michel
  • Strnad, Pavel
Type
Published Article
Journal
BMC Gastroenterology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2012
Volume
12
Pages
147–147
Identifiers
DOI: 10.1186/1471-230X-12-147
PMID: 23078008
Source
Medline
License
Unknown

Abstract

Keratin variants are expressed in a low percentage of patients with alcoholic cirrhosis and do not influence HCC development. Further studies conducted in larger prospective cohorts are needed to find out whether presence of K8 R341H variant predispose to non-HCC-related liver mortality.

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