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Keeping the CNS clear: glial phagocytic functions in Drosophila.

Authors
  • Kurant, Estee1
  • 1 Department of Anatomy and Cell Biology, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. [email protected] , (Israel)
Type
Published Article
Journal
Glia
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2011
Volume
59
Issue
9
Pages
1304–1311
Identifiers
DOI: 10.1002/glia.21098
PMID: 21136555
Source
Medline
License
Unknown

Abstract

Elimination of unwanted and potentially harmful matter is crucial for nervous system development and function. Glia are the main cleaners of the CNS that perform their function through engulfment and degradation of dying neurons and degenerating neuronal branches, developing excessive axons and synapses. Recent studies in Drosophila melanogaster have enhanced significantly our understanding of the phagocytic functions of glia and demonstrated that Drosophila provides an excellent model for investigating the molecular and cellular basis of glial phagocytosis. The current knowledge and great potential of this model, which is reviewed here, can open new directions in mammalian glial biology.

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