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Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine.

Authors
  • Lepeltier, Elise Anne1
  • Nuhn, Lutz2
  • Lehr, Claus-Michael1, 3
  • Zentel, Rudolf4
  • 1 Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), 66123 Saarbrücken, Germany. , (Germany)
  • 2 Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. , (Belgium)
  • 3 Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. , (Germany)
  • 4 Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, Mainz, Germany. , (Germany)
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
Jan 01, 2015
Volume
10
Issue
20
Pages
3147–3166
Identifiers
DOI: 10.2217/nnm.15.132
PMID: 26447353
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in tumor therapy and, on the other hand, provides alternative examples of nanomedicinal applications in immunotherapy, noninvasive drug deliveries across epithelial barriers and strategies to combat intra- and extra-cellular bacterial infections. Looking ahead, access to highly complex nanoparticular delivery vehicles given nowadays may allow further improved therapeutic concepts against several diseases in the future too.

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