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Juniperus communis Suppresses Melanoma Tumorigenesis by Inhibiting Tumor Growth and Inducing Apoptosis.

Authors
  • Gao, Hong-Wei1
  • Huang, Xiao-Fan2, 3
  • Yang, Tzi-Peng3, 4
  • Chang, Kai-Fu2, 3
  • Yeh, Ling-Wen3
  • Hsieh, Ming-Chang3, 4
  • Weng, Jun-Cheng5
  • Tsai, Nu-Man3, 4
  • 1 *Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. , (Taiwan)
  • 2 †Institute of Medicine of Chung Shun Medical University, Taichung, Taiwan. , (Taiwan)
  • 3 ‡Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan. , (Taiwan)
  • 4 §Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan. , (Taiwan)
  • 5 ¶Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan. , (Taiwan)
Type
Published Article
Journal
The American journal of Chinese medicine
Publication Date
Jan 01, 2019
Volume
47
Issue
5
Pages
1171–1191
Identifiers
DOI: 10.1142/S0192415X19500605
PMID: 31315419
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Melanoma, which has a high metastatic capacity and death rate, is a common skin cancer in Western countries. The purpose of this study was to address whether Juniperus communis (JCo) extract is effective in the suppression of melanoma and to elucidate the anticancer mechanisms involved in vitro and in vivo. The antitumor capacities of JCo extract on tumor suppression and toxicity were evaluated and the results demonstrated that the tumor burden was reduced via mediation of cell cycle, reduction of autocrine signaling, and induction of apoptosis. Moreover, JCo extract significantly prolonged the survival rate of the test subjects with only low pathological and physiological toxicity. Additionally, JCo extract also reduced cancer stem cell-related angiogenic and metastatic proteins in the process of tumor elimination. Based on these results, this study suggests that JCo extract suppresses tumor growth and induces apoptosis, and JCo extract may be useful for the prevention of melanoma tumorigenesis.

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