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Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials.

Authors
  • Williams, J T
  • Begleiter, H
  • Porjesz, B
  • Edenberg, H J
  • Foroud, T
  • Reich, T
  • Goate, A
  • Van Eerdewegh, P
  • Almasy, L
  • Blangero, J
Type
Published Article
Journal
American journal of human genetics
Publication Date
Oct 01, 1999
Volume
65
Issue
4
Pages
1148–1160
Identifiers
PMID: 10486334
Source
Medline
License
Unknown

Abstract

The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.

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