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The Joint Effect of Interleukin-12B rs3212227 Genotype and Behavioral Factors on Oral Cancer Risk in Taiwanese.

Authors
  • Li, Ching-Hao1
  • Sun, Kuo-Ting2
  • Li, Xin1
  • Shih, Liang-Chun1, 3, 4
  • Chen, Liang-Yu3
  • Yu, Chien-Chih4
  • Wang, Yun-Chi4
  • Chang, Wen-Shin1, 4
  • Tsai, Chia-Wen1, 4
  • Li, Chi-Yuan1
  • Bau, DA-Tian5, 4, 6
  • 1 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. , (China)
  • 2 Division of Pediatric Dentistry, China Medical University Hospital, Taichung, Taiwan, R.O.C. , (China)
  • 3 Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C. , (China)
  • 4 Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan, R.O.C. , (China)
  • 5 Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. [email protected] [email protected] , (China)
  • 6 Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C. , (Taiwan)
Type
Published Article
Journal
Anticancer Research
Publisher
International Institute of Anticancer Research
Publication Date
Dec 01, 2019
Volume
39
Issue
12
Pages
6515–6521
Identifiers
DOI: 10.21873/anticanres.13866
PMID: 31810916
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oral cancer is of the highest incidence worldwide in Taiwan, and a better marker for personalized therapeutic strategies such as immunotherapies is urgently needed. Interleukin-12 (IL12) is a cytokine that has been reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. The current study aimed at investigating whether IL12B rs3212227 genotype is associated with oral cancer in Taiwan. Genotypic characteristics of IL12B rs3212227 were determined among 958 oral cancer cases and age- and gender-matched individuals via typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. The AA, AC and CC genotypes of IL12B rs3212227 were 38.2, 38.9 and 22.9% in the case group and 36.2, 41.5 and 22.3% in the control group (p=0.5189), respectively. IL12B rs3212227 genotype was associated with oral cancer risk only in betel quid chewers. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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