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Jingzhaotoxin-XII, a gating modifier specific for Kv4.1 channels.

Authors
  • Yuan, Chunhua
  • Liao, Zhi
  • Zeng, Xiongzhi
  • Dai, Longjun
  • Kuang, Fang
  • Liang, Songping
Type
Published Article
Journal
Toxicon
Publisher
Elsevier
Publication Date
Oct 01, 2007
Volume
50
Issue
5
Pages
646–652
Identifiers
PMID: 17631373
Source
Medline
License
Unknown

Abstract

Jingzhaotoxin-XII (JZTX-XII), a 29-residue polypeptide, was purified from the venom of the Chinese tarantula Chilobrachys jingzhao. Electrophysiological recordings carried out in Xenopus laevis oocytes showed that JZTX-XII is specific for Kv4.1 channels, with the IC50 value of 0.363 microM. It interacts with the channels by modifying the gating behavior. JZTX-XII shares 80% sequence identity with phrixotoxin1, a potent inhibitor for Kv4.2 and Kv4.3 channels. Structure analysis indicates that the difference of the charge distribution in the interactive surface perhaps influences the specific pharmacology of the toxins. JZTX-XII should be a valuable tool for the investigation of the Kv4.1 channels.

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